Development of Novel Alpha-helix Mimetics

MSc in Medicinal Chemistry

Development of Novel Alpha-helix Mimetics

Supervisor: Dr Aniello Palma

A number of projects at Masters level are available in the field of supramolecular organic chemistry and medicinal chemisdtry in the group of Dr Aniello Palma:

Protein-protein interactions (PPI) play a key role in many biological processes. The ability to control and modulate PPIs would allow us to (i) better understand complex biological systems, (ii) establish novel approaches for medical diagnostics of various diseases and (iii) develop novel therapeutics. Of particular interest to my research are PPIs mediated by alpha-helices; these account for more than 60% of all known PPIs. The student working on this project will design and synthesise a new class of multi-facial alpha-helix mimetics based on non-natural amino acids.

The successful candidates will be based at the University of Kent’s Canterbury campus, and will work under the supervision of Dr Aniello Palma. In joining our team you will develop a deep understanding of multi-step synthetic chemistry and will gain experience in a wide range of experimental and analytical techniques.

Entry requirements and fees: Applicants should have/expect to obtain, a first or upper second class honours degree (or equivalent) in Chemistry or a related subject. This is a self-funded position and candidates will be liable for tuition fees at the standard rate (£4,327 for UK/EU candidates).


Contact: For further information or informal enquiries, please contact Dr Aniello Palma (

How to Apply: To apply please go to

You will need to apply through the online application form on the main University website. Please note that you will be expected to provide personal details, education and employment history and supporting documentation (Curriculum Vitae, transcript of results, two academic references).

Deadline Date for Applications: Open call